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Preventing Pancreatic Cancer Metastasis By Keeping Cells ‘Sheltered In Place’

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Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that pancreatic cancer metastasis–when tumor cells gain the deadly ability to migrate to new parts of the body–can be suppressed by inhibiting a protein called Slug that regulates cell movement. The study, published in the Journal of Experimental Medicine, also revealed two druggable targets that interact with Slug and hold promise as treatments that may stop the spread of pancreatic cancer.

“Pancreatic cancer cells are notorious for their ability to escape from a tumor. Even when pancreatic cancer is caught early, tumor cells are already found circulating throughout the body,” says Cosimo Commisso, Ph.D., an associate professor in Sanford Burnham Prebys’ NCI-designated Cancer Center and senior study author. Read more . . . 

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