Veliparib is a PARP inhibitor that is not yet approved by the FDA for use in any setting, says O’Reilly. A phase II trial presented at the 2020 Gastrointestinal Cancers Symposium examined the addition of veliparib to cisplatin and gemcitabine in treatment-naïve patients with stage III or IV pancreatic cancer with a germline BRCA1/2 or PALB2 mutation. Although a benefit was not observed with the addition of veliparib to combination chemotherapy, a very encouraging survival signal was reported, says O’Reilly. Watch here . . .
Eileen O’Reilly, MD, Winthrop Rockefeller Endowed Chair in Medical Oncology; co-director of Medical Initiatives at the David M. Rubenstein Center for Pancreatic Cancer Research; section head of Hepatopancreaticobilary and Neuroendocrine Cancers; and medical oncologist at Memorial Sloan Kettering Cancer Center, discusses the potential role of veliparib in pancreatic cancer.