Veliparib is a PARP inhibitor that is not yet approved by the FDA for use in any setting, says O’Reilly. A phase II trial presented at the 2020 Gastrointestinal Cancers Symposium examined the addition of veliparib to cisplatin and gemcitabine in treatment-naïve patients with stage III or IV pancreatic cancer with a germline BRCA1/2 or PALB2 mutation. Although a benefit was not observed with the addition of veliparib to combination chemotherapy, a very encouraging survival signal was reported, says O’Reilly. Watch here . . .