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Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort

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Given mitochondrial DNA (mtDNA) copy number in peripheral blood has been identified to be related to the risk of developing various cancers, but there exists very limited data on pancreatic ductal adenocarcinoma (PDAC), so, researchers addressed this subject in this study with 476 PDAC cases and 357 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

They analyzed peripheral leukocyte samples to ascertain relative mtDNA copy number. With advancing age and with a high BMI level, a lower mtDNA copy number was seen, and there was no link with gender, smoking behavior, and alcohol intake. Read more . . . 

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