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YAP1 is an Independent Prognostic Marker in Pancreatic Cancer and Associated with Extracellular Matrix Remodeling

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Pancreatic cancer is a major cause of cancer-related mortality. The identification of effective biomarkers is essential in order to improve management of the disease. Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo pathway, a signal transduction system implicated in tissue repair and regeneration, as well as tumorigenesis.

Here we evaluate the biomarker potential of YAP1 in pancreatic cancer tissue. YAP1 was selected as a possible biomarker for pancreatic cancer from global protein sequencing of fresh frozen pancreatic cancer tissue samples and normal pancreas controls. Read more . . . 

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