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Aiding Immune Responses Through CXCR4 Inhibition in Patients With Pancreatic Cancer

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For roughly 10 years, researchers at Cold Spring Harbor Laboratory  have been studying the tumor microenvironment in pancreatic cancer. More specifically, they are evaluating how it can prevent a T-cell attack of the cancer cells, said Douglas Fearon, MD.

In a phase I study, Fearon and his colleagues discovered that inhibiting the chemokine receptor type 4 (CXCR4) for one week can activate immune reactions in cancer cells and tumor biopsies. The study also led to the discovery that CXCR4 protects all of the cancer cells and CXCL-12 coats several adenocarcinomas. Read more . . .

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