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Research on the Establishment of a TPM3 Monoclonal Stable Transfected PANC-1 Cell Line and the Experiment of the EMT Occurrence in Human Pancreatic Cancer

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Tropomyosin (TPM) is an indispensable regulatory protein for muscle contraction, Abnormal expressions of TPM gene are closely related to the carcinogenesis and metastasis of malignant tumors.

In this experiment, a monoclonal stable transfected cell line was established by the knock-down of TMP3 expression in PANC-1 cells with the lentivirus method, and the impacts of the downregulated TPM3 gene expression on the EMT-related molecules and biological behaviors of PANC-1 cells were explored. Read more . . .

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