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High Glucose Microenvironment Accelerates Tumor Growth via SREBP1-Autophagy Axis in Pancreatic Cancer

High Glucose Microenvironment Accelerates Tumor Growth via SREBP1-Autophagy Axis in Pancreatic Cancer
Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor involved in both lipid metabolism and tumor progression. However, the relationship between high glucose microenvironment, SREBP1 and pancreatic cancer remains to be explored.

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