Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging “fuel” through an alternative supply route, called macropinocytosis. Scientists are hopeful that blocking this process, often described as “cellular drinking,” could lead to tumor-starving drugs. First, however, fundamental information is needed—such as the invisible molecular signals that drive the process.
Now, scientists from Sanford Burnham Prebys have identified a signaling pathway that regulates macropinocytosis, the nutritional cue that triggers the process and key metabolic differences between tumors—revealing new directions for drug development and patient treatment. Read more . . .