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p21-Activated Kinase 3 Promotes Cancer Stem Cell Phenotypes through Activating the Akt-GSK3β-β-Catenin Signaling Pathway in Pancreatic Cancer Cells

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Relative to several other p21-activated kinase (PAK) family members, the role of PAK3 in regulating cancer cell functions remains unclear. Our study obtained evidence that PAK3 regulates the Akt-GSK3β-β-catenin signaling by acting as Ser473-Akt kinase in several pancreatic cancer cell lines.

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