Pancreatic cancer is one of the most lethal diseases in the world, with five-year-survival rate less than 9%. The poor prognosis of pancreatic cancer is related to several factors, including the early occurrence of metastatic disease. Only 20% of patients who are in a non-metastatic stage have chance to receive curative surgery, while the remainder are not eligible for surgery in an advanced or metastatic stage.
It is therefore necessary to explore the mechanisms responsible for metastasis of pancreatic cancer to allow the development of effective therapeutic strategies. However, we lack effective models mimic the process of metastasis in vitro currently, which hinders our study on the molecular mechanism of tumor metastasis to some aspect. Read more