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Lynparza Successful in Pancreatic Cancer Trial

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AstraZeneca and MSD have announced positive results from the Phase III POLO trial, in which there was a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with Lynparza (olaparib) for pancreatic cancer, making it the first PARP inhibitor to demonstrate benefit in the disease.

The drug is a first-in-class PARP inhibitor, and the first targeted treatment to block DNA damage response in cells or tumours harbouring a deficiency in homologous recombination repair (HRR), such as mutations in BRCA1 and/or BRCA2. Read more . . .

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