To elevate therapeutic effectiveness of treatments and overt their toxicity, significant enthusiasm was generated to exploit new strategies for combating PDAC. Combination therapy targeting different barriers to mitigate delivery issues, reduce tumor recurrence and metastasis has demonstrated optimal outcomes in patients’ survival and quality of life, providing possible approaches to overcome therapeutic challenges.
This manuscript aims to provide an overview of currently explored multi-modal therapies using either conventional therapy or nanomedicines along with rationale, up-to-date progress, as well as the key challenges that must be overcome. Read more . . .