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SM-88 Shows Promise in Advanced Pancreatic Cancer

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M-88, a novel oral compound, has shown encouraging efficacy in early-stage data, said Allyson, J. Ocean, MD, but most importantly, the agent seems to be very well tolerated in patients with metastatic pancreatic cancer.

In an open-label, single-arm, phase II study presented at the 2019 Gastrointestinal Cancers Symposium, 28 evaluable patients with initial stage II, III, or IV disease, were treated with the regimen, which is comprised of a tyrosine derivative (D,L-alpha-metyrosine), an mTOR inhibitor (sirolimus), a CYP3a4 inducer (phenytoin), and an oxidative stress catalyst (methoxsalen). After a median follow-up of 4.3 months after treatment initiation, 67.8% of patients were alive and still on treatment, said Ocean, who is an associate professor of clinical medicine at Weill Cornell Medicine and NewYork-Presbyterian. Read more . . .


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