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Genetic Mutation May Increase Risk of Pancreatic Cancer in Females

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In a new study from Lawson Health Research Institute and Western University’s Schulich School of Medicine & Dentistry, researchers have found that mutation of a gene called ATRX may lead to increased risk of developing pancreatitis and pancreatic cancer in females. The study marks the first time a sex-specific genetic risk factor for pancreatic cancer has been identified.

The research team examined the effects of ATRX mutation in the adult pancreas using preclinical models. They deleted the ATRX gene and then studied its effect on susceptibility to pancreatic cancer. The team discovered that deleting the gene in females increased susceptibility to pancreatic damage associated with pancreatitis and increased progression to pancreatic cancer. Read more . . . 

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