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Pancreatic Cancer CTCs Harvested by Leukapheresis Yield Organoids

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Circulating tumor cells (CTCs) collected during leukapheresis from patients with pancreatic ductal adenocarcinoma (PDAC) successfully propagated organoids, according to a study presented at the 2018 AACR Pancreatic Cancer: Advances in Science and Clinical Care conference in Boston, Massachusetts.

Organoid modeling from needle biopsies of pancreatic tumors could predict clinical response to therapy, but this approach is invasive and technically challenging. Another approach is using CTCs, but this has been limited because CTCs generally produce a low yield of organoids. The aim of this study was to determine if CTCs harvested from leukapheresis would provide enough material to successfully propagate organoids. Read more . . . 

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