Pancreatic cancer often spreads, forming metastases in the liver or lungs. The prognosis is better for patients with metastases in the lungs. However, the organ that is more likely to be affected depends on the cancer cells’ ability to alter their characteristics and shape – as a research team at the Technical University of Munich (TUM) has discovered.
Cells in a tissue or tumor establish contacts with other cells and assume a scale-like appearance. Cancer cells that form metastases, however, must first alter their shape and characteristics. They have to modify their metabolism and detach themselves from the cluster of cells making up the tumor. Read more . . .