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Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer

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Are there germline mutations in cancer predisposition that are associated with pancreatic cancer?

In a case-control study that included 3030 patients with pancreatic cancer and 123 136 reference controls, 6 genes were independently associated with pancreatic cancer, with odds ratios between 2.58 and 12.33 after correction for multiple comparisons. In aggregate, these genes were observed in 5.5% of patients with pancreatic cancer. Read more . . . 

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