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Bitter Taste Receptors Promote Chemoresistance in Pancreatic Ductal Adenocarcinoma

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Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, making up more than 80 percent of cases. It begins in the cells of the pancreas’s ducts. Pancreatic cancer is the fourth most common cause of global cancer-related deaths, and is almost always fatal.

Bitter taste receptors (T2Rs) are G-protein coupled transmembrane proteins initially identified in the gustatory system as sensors for the taste of bitter. Recent evidence on expression of these receptors outside gustatory tissues suggested alternative functions, and there is growing interest of their potential role in cancer biology. Read more . . .

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