Research Probes Key Protein’s Role in Cancer Cell Growth

Newsfeed Image, Light Gray Text On Dark Gray Background
The oncogene RAS is the most frequently mutated gene of its type in human cancer. Active mutants are found in 60 to 90 percent of cases of pancreatic cancer, and a significant portion of colorectal and lung cancers.

Among all RAS-driven cancers, the most frequently mutated gene is KRAS. Two variants of this gene – K-Ras4A and K-Ras4B – also have important signaling functions and can promote cancer cell proliferation if mutated, so gaining a better understanding of their regulation and function could lead to development of improved cancer therapeutics. Read more . . .