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Neoadjuvant Therapy vs Upfront Resection for Pancreatic Cancer: The Actual Spectrum and Clinical Burden of Postoperative Complications

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In this study, researchers sought to assess the effect of neoadjuvant therapy (NAT) on surgical complications in patients who underwent pancreatic resections for PDAC. They observed a reduced incidence of pancreatic fistula and postpancreatectomy hemorrhage (PPH) but increased incidence of delayed gastric emptying (DGE) among patients undergoing pancreaticoduodenectomies (PD) for PDAC after NAT, compared with patients treated with underwent upfront surgery (UFS).

Patients receiving NAT were associated with increased clinical burden among those developing postoperative complications after PD. Read more . . .

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