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Blocking Enzyme in Normal Cells may Impede Pancreatic Cancer, Penn Vet Team Shows

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Cancer of the pancreas is a deadly disease, with a median survival time of less than six months.

Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer’s insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.

New findings from a University of Pennsylvania-led team offer a promising target for future therapies that could potentially root out even well-hidden metastatic cancer lesions. When they deleted the gene encoding this protein in mice with the disease, the animals lived longer, and the cancer’s spread to other organs was reduced. Read more . . .

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