There has been great interest in finding structural targets in cancer for the widely prescribed type 2 diabetes drug metformin. Metformin is a synthetic product derived from galegine, a guanide natural product found in French lilac. Documented use of galegine for human disease dates back to 1620, when John Parkinson first described the use of lilac plants for medicinal purposes in his treatise Theatrum Botanicum. Despite this long history, defining all relevant structural targets for metformin remains a challenge.
Repurposing of metformin for cancer is currently being explored in multiple clinical trials of prevention and treatment. Read more . . .