Purported benefits of this approach include the selection of patients with favorable tumor biology and a physiologic profile appropriate for major surgery, early treatment of micrometastatic disease, facilitation of a margin-negative resection, and guaranteed delivery of all components of multimodality therapy.
During the past 3 decades, refinement of the therapeutic regimens administered in the preoperative setting has permitted the rational use of potentially curative surgery in patients with anatomically advanced cancer and has contributed to a significant increase in overall survival duration following pancreatectomy. Read more . . .