Hyaluronan (HA) is a naturally occurring polysaccharide. “HA is secreted in excessive amounts in many pancreas cancers into the interstitium,” said Sunil R. Hingorani, MD, PhD, of the Fred Hutchinson Cancer Research Center in Seattle. PEGPH20, a pegylated form of recombinant human hyaluronidase PH20, has been shown in preclinical studies to degrade intratumoral HA. The subsequent decrease in fluid pressures can improve blood flow, allowing better drug delivery to the tumor bed. Read more . . .
Adding PEGPH20 to nab-paclitaxel and gemcitabine improved progression-free survival in patients with untreated, metastatic pancreatic ductal adenocarcinoma, according to a new study.