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Immune Cells Localized Near Pancreatic Cancer Cells Have Altered Metabolism, Could Promote Cancer

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A diagnosis of pancreatic cancer is a virtual death sentence, with only 3 to 5 per cent of patients surviving beyond five years. A key reason that it has the lowest survival rate of all major cancers is that it readily spreads from the pancreas to other parts of the body. However, its extreme mobility has remained a mystery.

Now, A*STAR researchers have uncovered compelling evidence that tumors in the pancreas change the metabolism of white blood cells known as macrophages (see image)1, which are described as the vacuum cleaners of the body because they gobble up microbes and cell debris. The team also found that these macrophages with altered metabolism may be involved in promoting the spread of cancer.            Read more . . .     

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