The model relies on induced pluripotent stem cell conversion; the artificially generated cell lines exhibit the PDAC phenotype and are expected to help our understanding of pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) tumors, typical manifestations of pancreatic cancer, are known to be strongly resistant to radiation therapy and chemotherapy. For finding a cure for the disease, it is essential to develop representative mouse models of PDAC tumors. An international team of researchers including Masaharu Seno and colleagues from Okayama University have now devised a new method for generating PDAC tumors in vivo — providing a promising platform for investigating pancreatic cancer. Read more . . .