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Immune System Infighting Explains Pancreatic Cancer’s Aggression

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Internal conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer.

Curbing this infighting has the potential to make treatment more effective, according to a study led by researchers from NYU Langone Medical Center and its Perlmutter Cancer Center.

The study, which published Aug. 25 in Cell, describes how a powerful subset of immune cells, known as “gamma delta T cells,” prevents other tumor-fighting T cells from entering pancreatic tumors. Without interference from gamma delta T-cells, CD4 and CD8 cells multiply and actively attack tumors the way they attack invading viruses or bacteria. Unfortunately, the immune system generates a large number of pro-tumor gamma delta T cells that infiltrate pancreatic tumors. Read more . . .

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