This study evaluated how obesity influences tumor growth, progression, and treatment response in several animal models of pancreatic ductal adenocarcinoma (PDAC). These findings were confirmed in samples from patients with cancer, explained Dai Fukumura, MD, PhD, Steele Laboratory of Tumor Biology in the Massachusetts General Hospital Department of Radiation Oncology and associate professor of Radiation Oncology at Harvard Medical School, Boston, Massachusetts, and co-senior author of the study. Read more . . .
Researchers revealed the mechanism by which obesity increases inflammation and desmoplasia — an accumulation of connective tissue — in the most frequent type of pancreatic cancer, in mouse models and human tissue samples.