“These three drugs, used in combination in a laboratory setting, prevented disease metastasis,” said Arsen Osipov, MD, program lead in the Pancreatic Cancer Multidisciplinary Clinic and Precision Medicine Program at Cedars-Sinai Cancer and senior and corresponding author of the study. “By focusing on the difficult-to-treat tumor microenvironment, we were able to amplify an immune response while simultaneously…
Now, researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Irving Medical Center have discovered a protein whose level of expression functions as a molecular switch between primary cancer growth and metastatic dissemination in PDA cells. The study, published online June 24 in Molecular Cell, provides key insights towards a possible treatment that can toggle…
The researchers believe this fundamental discovery could ultimately pave the way for new pancreatic cancer treatments. Researchers from The Institute of Cancer Research, London, studied pancreatic cancer with the gene that makes the GREM1 protein switched off in mice, and in pancreatic ‘mini-tumours’, which are also known as organoids. Read more . . .
In last week’s issue of the journal Molecular Cell, Christopher Chang and his group at UC Berkeley, collaborating with Christine Chio’s team at Columbia University in New York, report that metastasis is triggered by the loss of an enzyme that repairs oxygen damage to proteins. Read more . . .
The study included 347 carriers in the Netherlands who participated in surveillance for pancreatic ductal adenocarcinoma in a program initiated in the year 2000 at Leiden University Medical Center. Surveillance included annual magnetic resonance imaging with magnetic resonance cholangiopancreatography and optional endoscopic ultrasound. Read more . . .
“Combination chemotherapy remains the mainstay of treatment. That hasn’t changed, and it’s not going to change anytime soon, whether we’re talking about localized disease or advanced disease,” Philip said. “However, exploiting DNA repair defects in the form of BRCA1/2 mutations is now an established form of treatment, and we’re trying to expand that into other mutations.”…
The study revealed biomarkers of response, particularly to the sotigalimab/chemotherapy and nivolumab/chemotherapy combinations, Padrón explains. Moreover, in the patients’ blood and tumor at baseline, investigators found signals that correlated with longer survival, Padrón adds. Watch here . . .
The study involved data from 1,461 high-risk individuals enrolled in CAPS5 between 2014 and 2021 and from a total of 1,731 high-risk individuals enrolled in the total CAPS cohort, comprising the CAPS1–5 studies; the CAPS1–4 studies were single-institution studies initiated at Johns Hopkins in 1998. High-risk was defined as lifetime risk ≥ 5% based on…
“These exciting data suggest that the addition of a calcium channel blocker to gemcitabine may have some benefits, especially since calcium channel blockers have a very favorable toxicity profile, are low cost and are readily available,” said Thao Pham, PhD, research assistant professor of Medicine in the Division of Hematology and Oncology and a co-author of the study. Hidayatullah Munshi,…
Researchers extracted data from the North American Association of Central Cancer Registries (NAACCR) for the years 1995 to 2018. The NAACCR dataset consists of information from all US-based cancer registries, including patient demographics and medical history. The present analysis categorized all cases of invasive pancreatic cancer as either EOPC or late-onset pancreatic cancer (LOPC) based…