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Preclinical Study: Three-Step Treatment Strategy for Pancreatic Cancer

“These three drugs, used in combination in a laboratory setting, prevented disease metastasis,” said Arsen Osipov, MD, program lead in the Pancreatic Cancer Multidisciplinary Clinic and Precision Medicine Program at Cedars-Sinai Cancer and senior and corresponding author of the study. “By focusing on the difficult-to-treat tumor microenvironment, we were able to amplify an immune response while simultaneously…

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Discovery of a Molecular Switch in Pancreatic Cancer Cells that Triggers Metastatic Disease

Now, researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Irving Medical Center have discovered a protein whose level of expression functions as a molecular switch between primary cancer growth and metastatic dissemination in PDA cells. The study, published online June 24 in Molecular Cell, provides key insights towards a possible treatment that can toggle…

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Scientists Discover Mechanism Controlling Spread of Pancreatic Cancer

The researchers believe this fundamental discovery could ultimately pave the way for new pancreatic cancer treatments. Researchers from The Institute of Cancer Research, London, studied pancreatic cancer with the gene that makes the GREM1 protein switched off in mice, and in pancreatic ‘mini-tumours’, which are also known as organoids. Read more . . . 

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Scientists Find Trigger that Sets off Metastasis in Pancreatic Cancer

In last week’s issue of the journal Molecular Cell, Christopher Chang and his group at UC Berkeley, collaborating with Christine Chio’s team at Columbia University in New York, report that metastasis is triggered by the loss of an enzyme that repairs oxygen damage to proteins. Read more . . . 

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KRAS Mutations Represent Important Target in Expanding Treatment of Pancreatic Cancer

“Combination chemotherapy remains the mainstay of treatment. That hasn’t changed, and it’s not going to change anytime soon, whether we’re talking about localized disease or advanced disease,” Philip said. “However, exploiting DNA repair defects in the form of BRCA1/2 mutations is now an established form of treatment, and we’re trying to expand that into other mutations.”…

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Outcomes of Pancreas Surveillance in the CAPS5 Study and Total CAPS Cohort

The study involved data from 1,461 high-risk individuals enrolled in CAPS5 between 2014 and 2021 and from a total of 1,731 high-risk individuals enrolled in the total CAPS cohort, comprising the CAPS1–5 studies; the CAPS1–4 studies were single-institution studies initiated at Johns Hopkins in 1998. High-risk was defined as lifetime risk ≥ 5% based on…

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Calcium Channel Blockers May Improve Chemotherapy Response

“These exciting data suggest that the addition of a calcium channel blocker to gemcitabine may have some benefits, especially since calcium channel blockers have a very favorable toxicity profile, are low cost and are readily available,” said Thao Pham, PhD, research assistant professor of Medicine in the Division of Hematology and Oncology and a co-author of the study. Hidayatullah Munshi,…

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Early-Onset Pancreatic Cancer Increased in White and Hispanic Women

Researchers extracted data from the North American Association of Central Cancer Registries (NAACCR) for the years 1995 to 2018. The NAACCR dataset consists of information from all US-based cancer registries, including patient demographics and medical history. The present analysis categorized all cases of invasive pancreatic cancer as either EOPC or late-onset pancreatic cancer (LOPC) based…

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