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Physiotherapy for Quality of Life After Pancreatic Cancer Resection

Investigators equally randomized a total of 56 patients to intervention (n = 28) and control groups. The intensified physiotherapy intervention was comprised of endurance and muscle force exercises using cycle ergometer. The control group performed physiotherapy for 20 minutes five days a week, and only during their hospital stay. QoL was assessed with the Short…

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Genetically Modified Virus Helps Fight Advanced Pancreatic Cancer

It is about the results from a phase 1 clinical trial, which are published in the journal “Journal of ImmunoTherapy of Cancer”, and which show that the administration of this virus, called VCN-01, “is feasible and a possible new tool”in the treatment of advanced pancreatic cancer, explains Idibell in a statement this Wednesday. Read more  .…

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Breaking the Shield that Protects Pancreatic Cancer from Immunotherapy

“By targeting antigen-presenting cancer-associated fibroblasts, we might someday be able significantly to enhance the activity of immune therapy in pancreatic cancer patients,” said Huocong Huang, M.D., Ph.D., Instructor of Surgery at UTSW. Dr. Huang co-led the study with Rolf A. Brekken, Ph.D., Professor of Surgery, Pharmacology, and in UTSW’s Hamon Center for Therapeutic Oncology Research,…

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Increased Glucose Availability Sensitizes Pancreatic Cancer to Chemotherapy

Molecular analyses of tumors exposed to relatively high glucose levels revealed that a key metabolic pathway, glutathione biosynthesis, is diminished and underlies chemo-sensitization by enhancing oxidative injury to cancer cells. Inhibition of this pathway under normal conditions phenocopied a hyperglycemic state by enhancing chemotherapeutic efficacy in mouse PDAC, while rescuing the pathway under high glucose…

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