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Antibody Therapies Could Penetrate Pancreatic Cancer’s Shield if Research Pays Off

New research in mice has shed light on how antibodies could be harnessed to puncture the shield of scarlike cells that protect pancreatic cancer from treatment.The knowledge that cells called cancer-associated fibroblasts (CAFs) make up a significant portion of pancreatic tumors is nothing new. These scarlike cells can make tumors dense and tough, blocking chemotherapies…

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Drug combination yields highest response and longest survival rates for patients with pancreatic NETs

The trial was a randomized, phase 2 clinical trial comparing the effects of temozolomide alone with those of temozolomide in combination with capecitabine. The trial, which included 144 patients, showed that the combination of capecitabine and temozolomide produced longer progression-free survival rates, higher response rates, and longer overall survival rates than temozolomide alone. In addition,…

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Gallstone Disease Shown to be Strong Predictor of Pancreatic Cancer

“Pancreatic cancer can be difficult to diagnose and then chances of survival are slim. Our findings suggest that gallstone disease may be a way to better diagnose this type of cancer – meaning we could save more lives,” said Marianna Papageorge, MD, lead researcher on the study and research fellow at Boston Medical Center. Read…

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Gut Bacteria Linked to Immune Suppression in Pancreatic Cancer: Study

Lactobacillus – a type of bacteria thought to promote gut health – can alter the function of immune cells called macrophages in the pancreatic tumour environment and spur cancer growth, the researchers found. “Most studies focus on positive correlations between the microbiome and cancer outcomes,” said Tracy McGaha, a senior scientist at Princess Margaret Cancer Centre,…

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That New Fitbit Does More Than Count steps. It May Save Your Life One Day

Working with surgeons from the School of Medicine, Lu’s team has turned a Fitbit into a life-saving element of clinical care. Take pancreatic cancer. One of the best treatment options is surgery, Lu said, but it’s extremely risky. “Do you go through with the surgery or not? It’s a tough decision. But if you can predict…

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​New Findings on Bacteria that Increase Risk of Pancreatic Cancer

Cystic lesions, including intraductal papillary mucinous neoplasms (IPMNs), of the pancreas are common. Because they are known as precursors to pancreatic cancer, many patients need regular, lifelong check-ups, and a few can also require surgery. It would be valuable for the individual and for the health care to know more about the carcinogenic risk factors.…

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Pant Projects an Expanding Role for Targeted Therapy in Pancreatic Cancer

In today’s episode, we had the pleasure of speaking with Shubham Pant, MD, an associate professor in the departments of Investigational Cancer Therapeutics and Gastrointestinal Medical Oncology, and associate director in the Department of Sheihk Ahmed Center for Early Phase Drug Development of Pancreatic Cancer Research, in the Division of Cancer Medicine, at The University…

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Voruciclib Regimens Demonstrate Preliminary Potency Against KRAS-Positive Cancers

Treatment with voruciclib, a CDK9 inhibitor, as a monotherapy or in combination with sotorasib (AMG 510) and adagrasib demonstrated early activity in KRAS-mutant cancer cell lines, and synergistically inhibited growth of KRAS-mutant cancers in preclinical models, according to findings presented during Week 1 of the 2021 AACR Virtual Annual Meeting. Read more . . .

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Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis

Totally 36 patients with CP were enrolled in this study. Seven other cholangiocarcinoma patients without pancreas involvements or patients with benign pancreatic tumors were included as the control group. Total proteins in human pancreatic tissues were digested by trypsin, and ADMA-containing peptides were enriched via immunoaffinity purification. The LC-MS/MS was performed to characterize ADMA-containing peptides…

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