Research Probes Key Protein’s Role in Cancer Cell Growth

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The oncogene RAS is the most frequently mutated gene of its type in human cancer. Active mutants are found in 60 to 90 percent of cases of pancreatic cancer, and a significant portion of colorectal and lung cancers.

Among all RAS-driven cancers, the most frequently mutated gene is KRAS. Two variants of this gene – K-Ras4A and K-Ras4B – also have important signaling functions and can promote cancer cell proliferation if mutated, so gaining a better understanding of their regulation and function could lead to development of improved cancer therapeutics. Read more . . .

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