Immune Cells that Go Rogue and Prompt Pancreatic Cancer

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One challenge in treating pancreatic cancer is getting chemotherapy to reach the tumor cells. That’s because the tumors are surrounded by a forbidding microenvironment, a barrier of cells that both promote the tumor and block treatment.

Researchers have known the barrier is coordinated by cells from the body’s own innate immune system—macrophages that have been alternatively activated. But until now, researchers have known little about how the body’s inflammatory macrophages, which typically serve to get rid of harmful, foreign matter, go rogue and turn into tumor-enhancing cells. Read more . . .


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