Pancreatic ductal adenocarcinoma (PDAC), the most common type of malignancy of the pancreas, is extremely aggressive and very difficult to treat. Many scientists are currently investigating the genetic mutations and biochemical signalling pathways that enable cancer cells to spread to other parts of the body.
In a new study published in Nature Communications, researchers from Imperial College London have taken a different approach using cells in the lab. They have investigated how mechanical changes in a group of cells residing in the immediate environment of the tumour, called stellate cells, affect the progression of PDAC. Read more . . .